In vitro Evaluations of Cytotoxicity and Anti-inflammatory Effects of Peganum harmala Seed Extracts in THP-1-derived Macrophages

Aim: Based on knowledge from traditional Greco-Arab herbal medicine, this in vitro study aims to evaluate the cytotoxicity and the anti-inflammatory mechanism of Peganum harmala (P. harmala) seeds by measuring the expression and release of both anti-inflammatory (IL- 10) and pro-inflammatory (IL-1, IL-2, IL-6 and TNF-α) cytokines in human THP-1-derived macrophages. Methodology: Cells were treated with 1μg lipopolyssacharide/ml (LPS) in the absence and presence of increasing concentrations of extracts from the P. harmala seeds ...