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Evaluation of medicinal plant hepatotoxicity in co-cultures of hepatocytes and monocytes

Authors: 
Bashar Saad, Suha Dakwar, Omar Said, Ghassan Abu-Hijleh, Feras Al Battah, Abedelsalam Kmeel, Hassan Aziazeh
Journal Name: 
Evidence-Based Complementary and Alternative Medicine
Volume: 
3
Issue: 
1
Pages From: 
93
To: 
98
Date: 
الأحد, يناير 1, 2006
Abstract: 
Non-parenchymal cells might play an important role in the modulation of xenobiotic metabolism in liver and its pharmacological and toxicological consequences. Therefore, the role of cell-to-cell interactions in herbal induced liver toxicity was investigated in monocultures of cells from the human hepatocyte cell line (HepG2) and in co-cultures of cells from the HepG2 cell line and cells from the human monocyte cell line (THP1). Cells were treated with various concentrations (1–500 µg ml− 1) of extracts of Pistacia ...