Journal Name:
Toxicology and applied pharmacology
Volume:
126
Issue:
2
Pages From:
372
To:
379
Date:
الأربعاء, يونيو 1, 1994
Abstract:
The role of oxygen tension, insulin, and glucagon on the preservation and induction of
cytochrome P450 isoenzyme activities and contents was investigated in rat hepatocytes
cultured for 4 days on crude liver membrane fractions at 4 or 13% O2. At 13% O2, three out
of six immunochemically analyzed P450 isoenzymes were significantly higher than in 4%
O2. Exposure to phenobarbital (PB) from Days 1 to 4 dose dependently increased the
protein content and decreased the albumin secretion in 13% O2 cultures only. The ...