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Journal Name:
Toxicology in vitro
Volume:
8
Issue:
3
Pages From:
423
To:
435
Date:
Thursday, June 30, 1994
Abstract:
The influence of periportal-and centrilobular-equivalent oxygen tensions on cellular
functions and xenobiotic metabolism was investigated in rat hepatocytes cultured under
20%(air/CO 2), 13% or 4% O 2 for up to 9 days on teflon membrane dishes, coated with
crude membrane fractions and collagen. Protein content, total cytochrome P-450 content, 7-
ethoxy-resorufin-O-deethylase (EROD) and the profile of hydroxytestosterone metabolites
were not significantly affected by the oxygen tension, whereas intracellular lactate ...